January 30, 2016
Holoprosencephaly
can affect the fetus from a mild state to a severe state. Sometimes the body
will automatically abort the fetus if it is too severe. There’s significant
proportion of mildly affected children surviving past 12 months of age (Solomon,
2013). About half of all infants have chromosomal abnormalities, most often
they have trisomy 13.
The mothers’ age
has been associated as a risk factor. Women younger than 25 and older than 35
are at a higher risk for having an infant with holoprosencephaly.
Depending on if a
child has holoprosencephaly due to a chromosomal abnormality and the type, she
may have a recurrence risk for future children. There has been multiple
occurrences of holoprosencephaly without chromosomal abnormalities in the same
family, which supports genetic or a hereditary basis for at least a portion of
the cases.
The sex of the infant does influence the risk for having holoporsencephaly.
It is more common in females than it is in the males.
Also a case-control study suggests that risk of holoprosencephaly may be
increased with maternal use of misoprostol, a synthetic prostaglandin used for
elective termination (Birth Defect Risk Factor Series, 2005).
References:
Solomon, B. D. (2013, August 29). Holoprosencephaly Overview. Retrieved January 30, 2016, from
Birth Defect Risk Factor Series: Holoprosencephaly. (2005, November). Retrieved January 30, 2016,
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